Presbyterian Boys’ Secondary School (PRESEC) is a secondary boarding school for boys. It is located in Legon, Accra, Ghana. It was founded in 1938, under the auspices of the Presbyterian Church of the Gold Coast. 

The Basel missionary-theologian, Nicholas Timothy Clerk (1862–1961), who served as the first Synod Clerk of the Presbyterian Church of the Gold Coast from 1918 to 1932, used his tenure to advocate for the establishment of the secondary school. The school has ties with its sister schools, Aburi Girls’ Senior High School and Krobo Girls Senior High School.